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miR-17 ~ 92, an miRNA family containing three paralogous polycistronic clusters, was initially considered as an oncogene and was later demonstrated to trigger various physiological and pathological processes. Emerging evidence has implicated miR-17 ~ 92 family as a master regulator of neurogenesis. Through targeting numerous genes that affect cell cycle arrest, stemness deprivation, and miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. Patel V (1), Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, Igarashi P. The miR-17–92 cluster gene is primarily transcripted into an 800 bp long polycistron and is subsequently processed into 6 individual miRNAs (miR-17, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a). 12 The miR-17–92 cluster is broadly expressed at every stage of development, with the mature miRNAs detectable in almost all tissues at Survival analysis confirmed a high combined miRNA score of miR-17-92 cluster was associated with shorter biochemical recurrence interval. miR-17-92 cluster could be a potential diagnostic and prognostic biomarker for PCa, and the combination of the miR-17-92 cluster and serum PSA may enhance the accuracy for diagnosis of PCa. Endothelial cell death is linked to vascular diseases such as atherosclerosis and tissue ischemia. miRNA-17-92 (miR-17–92) is a multiple functional oncogenic miRNA cluster which plays vital roles in tumor angiogenesis and tissue development.
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During mouse preadipocyte 3T3L1 cell differentiation, we found that miR-17-92, a miRNA cluster that promotes cell proliferation in various cancers, was significantly up-regulated at the clonal expansion stage of adipocyte differentiation. Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocytes.
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468 , adm . t . v . 1794. Med den senare upplöser Bimreglering miRrors microRNA 17 ∼ 92 klusteruttryck i endotelceller in vivo inklusive miR-17 - 92-klustermedlemmar miR-17-5p och miR-92a-3p, som MicroRNA-17-92-klustret främjar proliferationen och kemokinproduktionen av keratinocyter: implikation för patogenesen av psoriasis. En av de bäst karakteriserade miRNA-klustren är det humana miR-17-92-klustret, även känt som oncomiR-1, kodar för sex hårnålstransskriptioner som bär sex Vi använde mRNA- och miRNA-sekvensering för att identifiera Foxm1-reglerade miRNA (andra än de i miR-17-92-klustret) med högnivåuttryck i NSC som Mir Amin Palace Hotel, Beiteddine: Se 152 recensioner, 209 bilder och bra erbjudanden på Mir Amin Palace Hotel, rankat #1 av 1 hotell i Beiteddine och med Skapa en resa för att spara och organisera alla dina reseidéer och se dem på en karta. Skapa en resa.
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Previous studies have shown that miR-17~92 promotes tumorigenesis and cancer angiogenesis in some tumor models. However, its role in the initiation and progression of CRC remains unknown. miR-17 ~ 92, an miRNA family containing three paralogous polycistronic clusters, was initially considered as an oncogene and was later demonstrated to trigger various physiological and pathological processes. Emerging evidence has implicated miR-17 ~ 92 family as a master regulator of neurogenesis.